Probing nuclear receptor biology in the immune system

Drug discovery efforts targeting nuclear receptors to treat disease

Aberrant activation of the immune system and how we can treat it

Using nuclear receptors to boost anti-tumor immunity

Welcome to the Solt Lab

The underlying theme of the research performed in the Solt laboratory is to understand the biologically relevant roles of nuclear receptors, a superfamily of ligand regulated transcription factors, in the immune system.  Our lab uses a combination of molecular biology, genetic, and chemical biology approaches coupled with mouse models of autoimmunity and chronic inflammation to study how different nuclear receptors’ expression, function, and activity affects disease.

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NEWS

August 2019
After an amazingly productive summer, we are sad to see our two summer undergraduate interns, Ashley Nichols and Rebecca Cameron, leave and head back to school. 

June 2019
A big welcome to our summer undergraduate interns, Ashley Nichols, a SURF intern from Chapman University, and Rebecca Cameron, from the University of Florida!

June 2019
Nature Index ranks Scripps Research the #1 non-profit scientific institute in the U.S.

May 2019
Team effort: collaboration between Solt lab, High throughput screening, Kojetin lab, and Kamenecka lab pays off!  We have been awarded a NIH R01 to screen for novel REV-ERB small molecules for cancer immunotherapy from the NCI.

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